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Derma Botanica's Retinol Cycling Duo, consisting of the Overnight Retinol Serum and Overnight Repair Serum
Derma Botanica Overnight Retinol Serum bottle with text highlighting its benefits on a white background
Derma Botanica Overnight Repair Serum bottle with text highlighting its benefits on a white background
Derma Botanica Retinol Serum Ingredients with text labels on a serum drop.
Derma Botanica Repair Serum Ingredients with text labels on a serum drop.
Derma Botanica Overnight Retinol Serum before and after comparison of fine lines and wrinkles on skin with text indicating visible reduction.
Derma Botanica Overnight Retinol Serum is held by a hand, with product benefits displayed in a clinical study.
Derma Botanica Overnight Repair Serum before and after comparison in the reduction of fine lines and wrinkles.
Derma Botanica Overnight Repair Serum is held by a hand, with product benefits displayed in a clinical study.

Retinol Cycling Duo

Our renewal and repair pair for younger-looking skin.
4.8 (483 reviews)

Our two most advanced dermatologist-developed formulas, now in one results-driven routine, for first-time retinol users or anyone with sensitive skin.

Alternate between our Retinol and Repair Serums to visibly reduce signs of aging, improve skin tone and texture, and maintain skin balance, without dryness or irritation.

  • Builds retinol tolerance while keeping skin balanced
  • Alternates renewal and repair for consistent results
  • Targets visible fine lines, uneven tone, and dryness
Free Exfoliating Cleanser worth $47
With every $100+ purchase
Regular price$148.00 Sale price$126.00
Regular price Save 15%
60-Day Money-Back Guarantee

60-Day Money-Back Guarantee

See visible results after 60 days or your money back — even if the bottle’s empty.

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Free US Shipping Over $50

No hidden fees. Free delivery across the US mainland.

Dermatologist Developed

Dermatologist Developed

Expertly formulated with scientifically proven actives.

2 Steps. 1 Night Routine. Formulated to Work Together.

Each step in this system is designed to complement the next so you get smoother, stronger, brighter skin without irritation, dryness, or overload.

Step 1: Renew with Time-Release Retinol

Overnight Repair Serum

Overnight Repair Serum

Step 1: Renew with Time-Release Retinol

Overnight Repair Serum

Formulated to deliver visible results while minimizing the irritation and dryness often linked to traditional retinoids, this overnight serum uses our Liposome Encapsulation Technology™. It features a 3% Liposome Retinol Complex for gradual release of retinol over 8 hours while you sleep.

Liposomal Retinol visibly smooths lines, refines texture, and evens tone, while Peptides, Vitamin E, and our CalmResilience™ Complex strengthen the skin barrier to maintain comfort and help prevent irritation.

The result: Skin that feels stronger, looks more even, and appears visibly refreshed without redness or peeling.

  • Visibly smooths lines, refines texture, and improves tone
  • Strengthens skin while it renews, reducing irritation risk
  • 8-Hour Time-Release Delivery for steady, gentle results
  • Calms redness and supports a resilient skin barrier
What's Inside

  • Liposome Encapsulation Technology™

    Encapsulated in liposomes for controlled absorption, our retinol releases gradually over 8 hours to avoid harsh concentration spikes in the skin’s surface layers. This slow-release system smooths texture, improves firmness, and reveals younger-looking skin.

  • Ectoin + Vitamin E

    Locks in hydration and strengthens the skin barrier. Ectoin helps prevent dehydration, while Vitamin E calms visible irritation and defends against environmental stressors.

  • Melatonin + Amino Acid Complex

    Supports overnight recovery by syncing with the skin’s natural repair cycle, helping reduce visible inflammation, support collagen, and promote visible renewal.

  • CalmResilience™ Complex

    Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha helps fortify the skin barrier, reduce visible redness, and and smooth the look of stressed skin.

Dr. Sandy Skotnicki
Dr. Sandy Skotnicki MD, FRCPC, FABD, Board-Certified Dermatologist
"This smarter 8-hour time-release retinol from Derma Botanica offers maximum results with minimal irritation, making it perfect for those with sensitive skin."

What you'll notice

Week 1

Skin feels more hydrated, calm, and balanced, with a fresher, more even appearance as it adjusts to the cycling routine.

Week 2-4

Fine lines start to soften. Texture feels smoother and skin appears clearer and more even-toned, including areas that often respond more slowly to anti-aging care.

Ongoing Use

Skin feels stronger and more resilient. Contours look firmer, dullness fades, and your natural radiance becomes more noticeable.

Emilia’s Journey | Duration 2 months

"I’ve noticed my skin looks smoother and more even since I started using this retinol serum consistently. The dullness and fine lines I was worried about are fading, and my complexion feels brighter and softer without the redness or flaking I was concerned about."

Kellys’s Journey | Duration 4 weeks

“I’ve been using this serum as part of my routine, and it’s made such a difference. My skin feels more hydrated and has a healthy brightness in the morning. I usually have a hard time with products that contain actives because my skin is so sensitive, but this one hasn’t caused any irritation at all.”

Carmen’s Journey | Duration 2 weeks

“This left my skin feeling deeply moisturized and helped smooth out the uneven areas I’ve always struggled with. I wasn’t expecting a big transformation, so the results really surprised me. It’s definitely become one of those products I’d 100% recommend to anyone.”

Ana’s Journey | Duration 6 weeks

“My skin looks firmer and way less tired since I started using the retinol. I was nervous at first since I’ve had reactions before. But I used it every 2 nights on & off like they said and it’s been fine. I wish I started using it earlier!”

Hannah's Journey | Duration 3 Months

“My skin always looked red, irritated, and tight no matter what I tried. After consistently using this serum, the redness completely calmed down and my skin feels comfortable again. It looks much plumper and healthier. For the first time in a long while, I actually feel good about my skin.”

Megan’s Journey | Duration 3 months

“The retinol serum has made my skin look smoother and more even. I’ve always struggled with uneven tone and dullness, but I was worried retinol would be too harsh. This one felt surprisingly gentle. I didn’t get the flaking or redness I had with other retinol products.”

Good to know

Clean formula | Safe for all skin types | No parabens, sulfates, phthalates, or synthetic dyes | Non-comedogenic | Vegan | Cruelty-free

Overnight Retinol

Water/Aqua/Eau, Caprylic/Capric Triglyceride, Propanediol, Sodium Cocoyl Amino Acids, Sarcosine Potassium Aspartate, Magnesium Aspartate, Butylene Glycol, Glycosphingolipids, Helianthus Annuus (Sunflower) Seed Oil, Centella Asiatica Leaf Extract, Phyllanthus Emblica Fruit Extract, Withania Somnifera Root Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Ectoin, Punica Granatum Extract, Leuconostoc/Radish Root Ferment Filtrate, Lauryl Glucoside, Myristyl Glucoside, Polyglyceryl-6 Laurate, Sodium Benzoate, Potassium Sorbate, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Glycerin, Phospholipids, Retinol, Phenoxyethanol, Polysorbate 20, Carbomer, Tocopherol Acetate, Citric Acid, Melatonin, Fragrance (Parfum).


Overnight Repair Serum

Water/Aqua/Eau, Glycerin, Centella Asiatica Leaf Extract, Phyllanthus Emblica Fruit Extract, Withania Somnifera Root Extract, Propanediol, Niacinamide, Butylene Glycol, Glycosphingolipids, Phenoxyethanol, Oryza Sativa (Rice) Lipids, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Hyaluronate, Hydrolyzed Glycosaminoglycans, Hydrolyzed Hyaluronic Acid, Hyaluronic Acid, Tremella Fuciformis Polysaccharide, Polyglutamic Acid, Mandelic Acid, Aspartic Acid, Gluconolactone, Lactobionic Acid, Pseudoalteromonas Exopolysaccharides, Hydrolyzed Soy Protein, Rice Amino Acids, Hydrolyzed Adansonia Digitata Seed Extract, Proline, Tocopherol Acetate, Squalane, Bakuchiol, Oenothera Biennes Oil, Panthenol, Sodium Benzoate, Potassium Sorbate, Fragrance (Parfum).

2 Steps. 1 Night Routine. Formulated to Work Together.

Each step in this system is designed to complement the next so you get smoother, stronger, brighter skin without irritation, dryness, or overload.

Step 1: Renew with Time-Release Retinol

Overnight Repair Serum

Overnight Repair Serum

Step 1: Renew with Time-Release Retinol

Overnight Repair Serum

Formulated to deliver visible results while minimizing the irritation and dryness often linked to traditional retinoids, this overnight serum uses our Liposome Encapsulation Technology™. It features a 3% Liposome Retinol Complex for gradual release of retinol over 8 hours while you sleep.

Liposomal Retinol visibly smooths lines, refines texture, and evens tone, while Peptides, Vitamin E, and our CalmResilience™ Complex strengthen the skin barrier to maintain comfort and help prevent irritation.

The result: Skin that feels stronger, looks more even, and appears visibly refreshed without redness or peeling.

  • Visibly smooths lines, refines texture, and improves tone
  • Strengthens skin while it renews, reducing irritation risk
  • 8-Hour Time-Release Delivery for steady, gentle results
  • Calms redness and supports a resilient skin barrier
What's Inside

  • Liposome Encapsulation Technology™

    Encapsulated in liposomes for controlled absorption, our retinol releases gradually over 8 hours to avoid harsh concentration spikes in the skin’s surface layers. This slow-release system smooths texture, improves firmness, and reveals younger-looking skin.

  • Ectoin + Vitamin E

    Locks in hydration and strengthens the skin barrier. Ectoin helps prevent dehydration, while Vitamin E calms visible irritation and defends against environmental stressors.

  • Melatonin + Amino Acid Complex

    Supports overnight recovery by syncing with the skin’s natural repair cycle, helping reduce visible inflammation, support collagen, and promote visible renewal.

  • CalmResilience™ Complex

    Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha helps fortify the skin barrier, reduce visible redness, and and smooth the look of stressed skin.

Routine FAQs

Customer Reviews

Based on 483 reviews
88%
(426)
7%
(32)
5%
(23)
0%
(1)
0%
(1)
C
Cat F.
Age range: 35-44
Skin type: Normal
Love these products

Can’t say enough about how much I love the products!!

K
Kimberly F.
Easy routine to follow

Love that I don’t have to guess when to use what. Just alternate and go.

K
Kelsey
Retinol without the drama

I usually flake from retinol but this setup works. I alternate and wake up with happy skin.

J
Jenna
It’s like magic

One night retinol, one night healing. My skin is SO happy.

J
Jennifer c.
Game changer for my skin

I’ve tried retinol before but always had issues. This combo is gentle AND effective.

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We believe you deserve visible results: smoother, firmer, younger-looking skin that helps you feel confident every time you look in the mirror. That’s why every purchase is backed by our 60-day money-back guarantee. If you don’t love how your skin looks and feels, just send it back and get a full refund. No questions asked—even if the bottles are empty.

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