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Overnight Retinol Serum bottle, Clinicians' Choice

Before and after 6 weeks: 100% said their skin felt softer, smoother and more refined

Before and after 6 weeks: 83% reported improvements in skin tone and texture

Powerful retinol, engineered for comfort: liposome-encapsulated 0.5% retinol, 8-hour time release, built-in barrier support

Before and after 4 weeks: 100% reported no irritation, flaking or peeling

One serum, multiple jobs: softens lines and wrinkles, smooths texture, evens tone and dark spots, boosts radiance

Consumer study: 100% satisfied with results, 92% would continue using, 92% would recommend

Dr. Ellen Turner, MD, board-certified dermatologist, on why she recommends the serum

Five-star review from Lisa V., verified buyer

How to use: apply at night, build to nightly use, finish with moisturizer and daily SPF

Overnight Retinol Serum

Smoother, firmer, more even skin without redness, peeling, or irritation.

30ml / 1 fl. oz

Developed with dermatologists, this 0.5% Liposomal Retinol Serum with calming adaptogens visibly smooths fine lines, improves uneven tone, and reinforces the skin barrier.

The 8-Hour Time Release System delivers retinol while you sleep for visible anti-aging results without redness, peeling, or flaking. Gentle enough for sensitive skin, it restores a smoother, firmer, and younger-looking complexion overnight.

Select Your Supply

1 Bottle

$74.00

Start gently, see the glow for yourself

60-Day Money-Back Guarantee

See visible results after 60 days or your money back — even if the bottle’s empty.

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No hidden fees. Free delivery across the US mainland.

Dermatologist Developed

Expertly formulated with scientifically proven actives.

What you'll notice

Week 1

Your skin starts to feel smoother, calmer, and more balanced, without dryness or stinging.

Week 2-4

Fine lines look softened, texture feels smoother, and skin tone appears more even, for a brighter, youthful-looking complexion.

Ongoing Use

Skin looks clearer and more radiant. Fine lines and wrinkles appear softened, dark spots look diminished, and pores appear refined, leaving many users confident about going makeup-free.

Emilia’s Journey | Duration 8 weeks

“My smile lines look softer and my makeup sits so much better. This is the first retinol I actually want to keep using.”

Judita’s Journey | Duration 6 weeks

“Day to day I didn’t realize how much my skin was changing. Then I compared my photos. The texture looks so much smoother now, especially through my cheeks, and my skin just feels firmer and healthier.”

Becca's Journey | Duration 4 weeks

“The glow was the first thing I noticed. My skin used to look dull even when it was moisturized, and now it looks brighter and more even. I wasn’t expecting that much of a change in four weeks.”

Marissa’s Journey | Duration 4 weeks

“The biggest difference for me is the texture. My cheek looks smoother and more even now, and my skin just seems more refined overall.”

Callyn's Journey | Duration 4 weeks

“I mostly wanted my skin to look fresher. After four weeks, it looks more even, more awake, and it has that healthy glow I felt like I was missing.”

Why It Works

Liposome Encapsulation Technology™

Encapsulation helps create a steadier retinol release instead of one harsh hit all at once, so skin has a better chance to adjust.

8-Hour Time Release 

Retinol is released gradually while you sleep, helping reduce the sudden retinol exposure that can trigger redness, tightness, and flaking.

Built-In Barrier Support

Ectoin, vitamin E, melatonin, amino acids, and calming botanicals help support hydration and comfort while retinol works - so skin feels cushioned, less tight, and softer by morning.

One serum, multiple jobs

Fine lines, uneven texture, dullness, uneven tone, and loss of firmness are all supported in one simple nighttime step.

Dr. Dawn QueenBoard-Certified Dermatologist

“
A stand out retinol formula with gradual-release liposomal technology and barrier-supporting ingredients to target lines, texture, and discoloration while staying gentle on the skin. Over time, I noticed my skin looked more even and refreshed, without the irritation that can sometimes come with retinol.
”

Good to know

How to use

Step 1: Apply at Night

Use 2–3 pumps on clean, dry skin. Avoid the eye area.

Step 2: Moisturize (optional)

Follow with your preferred moisturizer to lock in hydration. If using our Adaptogenic Soothing Cream, apply it after the serum.

Usage Frequency Guidelines:

Stage 1: Cycling — Build Tolerance

If you are new to retinol or have sensitive skin, start gradually to help your skin adjust.

Apply 2–3 pumps to clean, dry skin twice a week, leaving at least one day between applications.
If your skin tolerates this without irritation, increase usage to every other night.
Once your skin adjusts to this frequency without irritation, progress to nightly use.

On Non-Retinol Nights 

Use the Overnight Repair Serum on alternate nights to complement retinol in your routine. Powered by the Multi-Layer Hydration System™ and Triple Renewal Complex™, it strengthens the barrier, calms sensitivity, and delivers retinol-like firming, brightening, and smoothing to help maintain visible anti-aging results.

Stage 2: Layering — Maximize Results

Once nightly retinol use feels comfortable, you can combine both overnight serums for enhanced benefits:

Apply the Overnight Retinol Serum first to target fine lines, uneven texture, and tone.
Follow with the Overnight Repair Serum to replenish hydration, reinforce the barrier, and minimize sensitivity. Together, they allow retinol to work effectively while keeping skin resilient — for smoother, firmer, and more even-looking results over time.

Additional Notes

Always apply SPF daily while using retinol.
Do not use if pregnant or breastfeeding.

Our 60 Day Guarantee

We believe you deserve visible results: smoother, firmer, younger-looking skin that helps you feel confident every time you look in the mirror.

That’s why every purchase is backed by our 60-day money-back guarantee.

If you don’t love how your skin looks and feels, just send it back and get a full refund. No questions asked—even if the bottles are empty.

Kelly R.

Verified Purchase

Obsessed!!

I was nervous to try this serum because it was my first time using retinol and I have sensitive skin. I did not experience any redness or irritation and truly believe it's due to its slow release properties. It was so gentle, yet effective, and actually felt good on my skin. I highly recommend this encapsulated retinol to anyone with sensitive skin!

Katelynn A.

Verified Purchase

This stuff is amazing!!! 🤩

As a skincare junkie, I’ve tried sooo many retinols and even after 1 use they’ve always made me red and peel, but I used this retinol EVERY SINGLE NIGHT for 4 weeks straight and it didn’t make me red or peel a single time plus it’s given me the brightest, glowing skin making it gentle, yet very effective!!! Absolutely love this stuff!!!

Amanda H.

Verified Purchase

It's changed my skin to glowing!!

A lovley light creamy serum .. I only use a little the photo shows just one pump! And it glides across the face and jawline. Absorbing super quick!

I've been using over the 2 weeks and love how my skin feels. I wake up feeling hydrated and plump and the condition overall has improved immensely.. really high quality active ingredients that don't irritate the skin. Just brilliant.

Read all reviews

What’s inside

Liposome Encapsulation Technology™
Encapsulated in liposomes for controlled absorption, our retinol releases gradually over 8 hours to avoid harsh concentration spikes in the skin’s surface layers. This slow-release system smooths texture, improves firmness, and reveals younger-looking skin.
Ectoin + Vitamin E
Locks in hydration and strengthens the skin barrier. Ectoin helps prevent dehydration, while Vitamin E calms visible irritation and defends against environmental stressors.
Melatonin + Amino Acid Complex
Supports overnight recovery by syncing with the skin’s natural repair cycle, helping reduce visible inflammation, support collagen, and promote visible renewal.
CalmResilience™ Complex
Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha helps fortify the skin barrier, reduce visible redness, and and smooth the look of stressed skin.

FULL INGREDIENTS LIST

Shared by people who tried it

Complete Your Routine and Save

Each set includes the Overnight Retinol Serum, paired with dermatologist-developed formulas designed to work together for faster, visible results.

best seller

Retinol Cycling Duo

Our retinol and recovery pair for visibly younger-looking skin.

$142.00

$126.00

derm recommended

The Full Anti-Aging System

Derm-developed anti-aging system for beginner retinol users.

$191.00

$143.00

derm recommended

The Full Anti-Aging System + Moisture Lock

A complete retinol routine to wake up with younger-looking skin.

$240.00

$156.00

Product FAQs

How long until I see results?

You may notice a smoother, more radiant glow within 2 - 4 weeks. More visible improvements in fine lines, texture, and tone typically appear after 8 - 12 weeks of consistent use. Retinol works gradually but delivers long-term transformation.

What percentage of retinol is in the serum?

The Overnight Retinol Serum contains 0.5% liposome-encapsulated retinol. This next-gen delivery system ensures the retinol is released gradually and deeper into the skin—maximizing results while minimizing irritation.

What makes this retinol different from others?

Unlike traditional formulas, this serum uses liposomal encapsulation technology to deliver retinol more efficiently with less surface irritation. It also includes our proprietary CalmResilience™ Complex, designed to soothe, hydrate, and support the skin barrier—making it ideal even for sensitive or first-time users.

Is this serum suitable for all skin types?

Yes, it's formulated for all skin types - including sensitive, dry, and oily skin. However, we recommend performing a patch test prior to full application, especially if you’re prone to sensitivity.

Is it safe to use during pregnancy or breastfeeding?

We recommend avoiding retinol during pregnancy or breastfeeding unless cleared by your doctor.

What should I do if I experience irritation?

Mild redness or dryness is normal when starting retinol. If you experience irritation:

Reduce usage to once or twice weekly
Always follow with a moisturizer
Apply sunscreen daily, as retinol increases sun sensitivity

If irritation persists, discontinue use and consult a dermatologist.

1 Bottle

Age range: 65+

Skin type: Sensitive, Combination

I have used it every night since receiving my order. I have never used a retinol product before because I was worried about my sensitive skin’s reaction but I have no irritation to this product. My skin seams to have more bounce to it. And that is a good thing for a 78 year old woman who was starting to look her age.

Age range: 55-64

Skin type: Normal

I’ve used numerous over the counter retinol creams including prescription trentinoin and this was

I’ve used numerous over the counter retinol creams including prescription trentinoin and this was the first product to improve my skin. My skin instantly looks luminous after applying and has become noticeably firmer over time. I also like how dewy my skin feels after applying. I definitely plan to order again.

Age range: 25-34

Skin type: Sensitive

Great for sensitive skin!

I’m getting into my thirties and have been wanting to just do some preventative maintenance on my skin texture and fine lines. I want to avoid Botox at all cost. I have really sensitive skin though and am very careful about what I use. This serum is so gentle you barely even realize it’s there. I’ve noticed a huge difference in the texture and tone of my skin especially. I don’t even feel the need to wear makeup on my skin too much but when I do everything melts in so nicely because of the texture now.

Age range: 35-44

Skin type: Combination

This stuff is amazing!!! 🤩

Age range: 35-44, 45-54

Skin type: Normal

Aesthetician approved!

This is a great retinoid for all skin types, even sensitive skin. It is encapsulated with a liposome, so it has a very gentle delivery system. My skin didn’t get irritated at all, and I saw amazing results. My skin was smoother, pores were more fine, and I didn’t get any of that irritation that you normally get with your typical retinoid

We believe you deserve visible results: smoother, firmer, younger-looking skin that helps you feel confident every time you look in the mirror. That’s why every purchase is backed by our 60-day money-back guarantee. If you don’t love how your skin looks and feels, just send it back and get a full refund. No questions asked—even if the bottles are empty.