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Three skincare products in a black box with 'Derma Botanica' branding on a green background.

Derma Botanica Overnight Retinol Serum bottle with text highlighting its benefits on a white background

Derma Botanica Overnight Repair Serum bottle with text highlighting its benefits on a white background

Derma Botanica Retinol Serum Ingredients with text labels on a serum drop.

Derma Botanica Repair Serum Ingredients with text labels on a serum drop.

Retinol Cycling Duo + Moisture Lock

The Overnight Ritual That Restores, Renews, and Nourishes

A dermatologist-developed night system that smooths, firms, and strengthens - without redness, peeling, or routine overload. This three-step ritual pairs time-release retinol, barrier-repair hydration, and restorative face oils, making it the perfect gift for someone you love, or a well-deserved ritual for yourself.

Firms, smooths, and evens tone without irritation
Three dermatologist-designed steps that work together
Gentle enough for sensitive skin, effective for all skin types

$191.00

$143.00

Save 25%

60-Day Money Back Guarantee

60-Day Money-Back Guarantee

See visible results after 60 days or your money back — even if the bottle’s empty.

Free US Shipping Over $50

No hidden fees. Free delivery across the US mainland.

Dermatologist Developed

Expertly formulated with scientifically proven actives.

Step 1: Renew with Time-Release Retinol

Overnight Retinol Serum

Step 1: Renew with Time-Release Retinol

Overnight Retinol Serum

Formulated to deliver visible anti-aging results while minimizing the irritation and dryness of traditional retinoids, this serum uses Liposome Encapsulation Technology™ for targeted, time-controlled release of retinol encapsulated in liposomes.

This 3% Retinol Complex works in three phases: right after application, an immediate dose is released to refine texture; an 8-hour gradual release renews skin overnight; and deep-layer delivery ensures retinol reaches where skin needs it most, delivering visible results.

The result: Visibly smoother, firmer, and more even-toned skin, refreshed by morning without redness or irritation.

Smooths lines and refines texture with retinol for visibly firmer skin
Hydrates, protects, and calms against stressors with Ectoin and Vitamin E
Boosts overnight renewal with Melatonin for refreshed skin by morning
Reinforces barrier strength and resilience with Amino Acid Complex

What's Inside

Liposome Encapsulation Technology™

Encapsulated in liposomes for controlled absorption, our retinol releases gradually over 8 hours to avoid harsh concentration spikes in the skin’s surface layers. This slow-release system smooths texture, improves firmness, and reveals younger-looking skin.
Ectoin + Vitamin E

Locks in hydration and strengthens the skin barrier. Ectoin helps prevent dehydration, while Vitamin E calms visible irritation and defends against environmental stressors.
Melatonin + Amino Acid Complex

Supports overnight recovery by syncing with the skin’s natural repair cycle, helping reduce visible inflammation, support collagen, and promote visible renewal.
CalmResilience™ Complex

Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha helps fortify the skin barrier, reduce visible redness, and and smooth the look of stressed skin.

FULL INGREDIENTS LIST

Step 2: Repair on Non-Retinol Nights

Overnight Repair Serum

Step 2: Repair on Non-Retinol Nights

Overnight Repair Serum

An overnight serum that maintains renewal and supports repair between retinol nights. Formulated with our Triple Renewal Complex™ with Bakuchiol, Niacinamide, and Plant Collagen, it supports collagen renewal, improves firmness, and visibly smooths fine lines.

Our Multi-Layer Hydration System™ with 5D Hyaluronic Acid replenishes hydration across multiple layers to help skin feel plump, soft, and visibly resilient.

The result: Hydrated, smoother, and more radiant-looking skin that maintains visible anti-aging progress between retinol nights.

Supports collagen renewal and improves firmness
Reduces visible hyperpigmentation and evens tone
Delivers deep, layered hydration without heaviness
Maintains balance and results between renewal nights

What's Inside

Triple Renewal Complex™

Bakuchiol, Niacinamide, and Plant Collagen visibly smooth fine lines, enhance firmness, and refine texture to deliver anti-aging benefits without irritation.
Multi-Layer Hydration System™

Five molecular weights of Hyaluronic Acid with Ceramides and Squalane deliver deep, lasting hydration, lock in moisture, and visibly plump the skin for a smoother look.
CalmResilience™ Complex

Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha calms visible redness, reduces signs of stress, and supports the skin’s natural resilience for a balanced, healthy-looking complexion.

FULL INGREDIENTS LIST

Step 3: Seal & Protect

Moisture-Locking Face Oil

Step 3: Seal & Protect

Moisture-Locking Face Oil

A fast-absorbing, non-comedogenic oil with a 9-Oil Blend, Squalane, and Vitamin E that seals in moisture and supports overnight recovery. It replenishes essential fatty acids to restore suppleness and provides antioxidant defense against daily stressors. The nourishing formula absorbs quickly without greasiness or clogging pores, leaving skin soft, smooth, and dewy-looking by morning.

The result: Skin that feels deeply nourished, supple, and visibly radiant.

Locks in hydration to prevent overnight moisture loss
Softens the look of fine lines and smooths skin texture
Enhances radiance with a healthy, dewy finish
Restores lipids for plumper, supple skin

What's Inside

9 Nourishing Natural Oils

A blend that mimics skin’s natural lipids to hydrate and protect. Jojoba locks in moisture, Marula delivers antioxidants and essential fatty acids, and Camellia provides deep hydration for skin that feels soft, smooth, and supple.
Squalane

Lightweight and non-comedogenic, it replenishes skin’s natural oils, helps prevent moisture loss, and calms the complexion while absorbing quickly without clogging pores.
Vitamin E

A powerful antioxidant that helps defend against environmental stressors, supports lasting hydration, and softens the look of fine lines and uneven texture.
CalmResilience™ Complex

Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha helps soothe skin, reduces visible redness, and reinforces barrier resilience.

FULL INGREDIENTS LIST

Dr. Dawn Queen MD, Board-Certified Dermatologist

"
A stand out retinol formula with gradual-release liposomal technology and barrier-supporting ingredients to target lines, texture, and discoloration while staying gentle on the skin. Over time, I noticed my skin looked more even and refreshed, without the irritation that can sometimes come with retinol.
"

What you'll notice

Week 1

Skin feels more hydrated, calm, and balanced, with a fresher, more even appearance as it adjusts to the cycling routine.

Week 2-4

Fine lines start to soften. Texture feels smoother and skin appears clearer and more even-toned, including areas that often respond more slowly to anti-aging care.

Ongoing Use

Skin feels stronger and more resilient. Contours look firmer, dullness fades, and your natural radiance becomes more noticeable.

Emilia’s Journey | Duration 2 months

“My smile lines look softer and my makeup sits so much better. This is the first retinol I actually want to keep using.”

Kelly’s Journey | Duration 4 weeks

“My skin finally stopped freaking out. No sting, no redness, just calm, soft skin every morning. I am not taking this out of my routine.”

Carmen’s Journey | Duration 2 weeks

"only 2 weeks and my skin feels way more hydrated. the uneven patches I've always had are smoother already, kinda shocked."

Ana’s Journey | Duration 6 weeks

“No peeling. No red flaky mess. Just smoother, brighter skin. I wish I found this retinol sooner.”

Hannah's Journey | Duration 3 Months

"my skin used to look red and feel tight constantly. 3 months in and it's actually calm. haven't felt this good about it in years."

Megan’s Journey | Duration 3 months

“My skin looks smoother, more even, and honestly younger. I have tried so many retinols. This is the one I am sticking with.”

Good to know

How to use

Stage 1: Cycling — Build Tolerance

If you’re new to retinol or have sensitive skin, start gradually to help your skin adjust.

Apply 2–3 pumps to clean, dry skin twice a week, leaving at least one day between applications.
If your skin tolerates this without irritation, increase usage to every other night.
Once your skin adjusts to this frequency without irritation, progress to nightly use.

On Non-Retinol Nights

Use the Overnight Repair Serum on alternate nights to complement retinol in your routine. Powered by the Multi-Layer Hydration System™ and Triple Renewal Complex™, it strengthens the barrier, calms sensitivity, and delivers retinol-like firming, brightening, and smoothing to help maintain visible anti-aging results.

Stage 2: Layering — Maximize Results

Once nightly retinol use feels comfortable, you can combine both overnight serums for enhanced benefits:

Apply the Overnight Retinol Serum first to target fine lines, uneven texture, and tone.
Follow with the Overnight Repair Serum to replenish hydration, reinforce the barrier, and minimize sensitivity. Together, they allow retinol to work effectively while keeping skin resilient for smoother, firmer, and more even-looking results over time.

Step 3: Seal with Moisture-Locking Face Oil

Finish with a few drops of oil, gently pressing it over the cream to lock in hydration and boost your skin’s natural glow.

Our 60 Day Guarantee

We believe you deserve visible results: smoother, firmer, younger-looking skin that helps you feel confident every time you look in the mirror.

That’s why every purchase is backed by our 60-day money-back guarantee.

If you don’t love how your skin looks and feels, just send it back and get a full refund. No questions asked—even if the bottles are empty.

Step 1: Renew with Time-Release Retinol

Overnight Retinol Serum

Step 1: Renew with Time-Release Retinol

Overnight Retinol Serum

The result: Visibly smoother, firmer, and more even-toned skin, refreshed by morning without redness or irritation.

Smooths lines and refines texture with retinol for visibly firmer skin
Hydrates, protects, and calms against stressors with Ectoin and Vitamin E
Boosts overnight renewal with Melatonin for refreshed skin by morning
Reinforces barrier strength and resilience with Amino Acid Complex

What's Inside

Liposome Encapsulation Technology™

Encapsulated in liposomes for controlled absorption, our retinol releases gradually over 8 hours to avoid harsh concentration spikes in the skin’s surface layers. This slow-release system smooths texture, improves firmness, and reveals younger-looking skin.
Ectoin + Vitamin E

Locks in hydration and strengthens the skin barrier. Ectoin helps prevent dehydration, while Vitamin E calms visible irritation and defends against environmental stressors.
Melatonin + Amino Acid Complex

Supports overnight recovery by syncing with the skin’s natural repair cycle, helping reduce visible inflammation, support collagen, and promote visible renewal.
CalmResilience™ Complex

Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha helps fortify the skin barrier, reduce visible redness, and and smooth the look of stressed skin.

FULL INGREDIENTS LIST

Step 2: Repair on Non-Retinol Nights

Overnight Repair Serum

Step 2: Repair on Non-Retinol Nights

Overnight Repair Serum

Our Multi-Layer Hydration System™ with 5D Hyaluronic Acid replenishes hydration across multiple layers to help skin feel plump, soft, and visibly resilient.

The result: Hydrated, smoother, and more radiant-looking skin that maintains visible anti-aging progress between retinol nights.

Supports collagen renewal and improves firmness
Reduces visible hyperpigmentation and evens tone
Delivers deep, layered hydration without heaviness
Maintains balance and results between renewal nights

What's Inside

Triple Renewal Complex™

Bakuchiol, Niacinamide, and Plant Collagen visibly smooth fine lines, enhance firmness, and refine texture to deliver anti-aging benefits without irritation.
Multi-Layer Hydration System™

Five molecular weights of Hyaluronic Acid with Ceramides and Squalane deliver deep, lasting hydration, lock in moisture, and visibly plump the skin for a smoother look.
CalmResilience™ Complex

Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha calms visible redness, reduces signs of stress, and supports the skin’s natural resilience for a balanced, healthy-looking complexion.

FULL INGREDIENTS LIST

Step 3: Seal & Protect

Moisture-Locking Face Oil

Step 3: Seal & Protect

Moisture-Locking Face Oil

The result: Skin that feels deeply nourished, supple, and visibly radiant.

Locks in hydration to prevent overnight moisture loss
Softens the look of fine lines and smooths skin texture
Enhances radiance with a healthy, dewy finish
Restores lipids for plumper, supple skin

What's Inside

9 Nourishing Natural Oils

A blend that mimics skin’s natural lipids to hydrate and protect. Jojoba locks in moisture, Marula delivers antioxidants and essential fatty acids, and Camellia provides deep hydration for skin that feels soft, smooth, and supple.
Squalane

Lightweight and non-comedogenic, it replenishes skin’s natural oils, helps prevent moisture loss, and calms the complexion while absorbing quickly without clogging pores.
Vitamin E

A powerful antioxidant that helps defend against environmental stressors, supports lasting hydration, and softens the look of fine lines and uneven texture.
CalmResilience™ Complex

Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha helps soothe skin, reduces visible redness, and reinforces barrier resilience.

FULL INGREDIENTS LIST

Routine FAQs

Who is this gift set best for?

Whether you’re shopping for your mom, sister, best friend - or yourself, this gift set is ideal for anyone looking to simplify their night routine while seeing real anti-aging results. It’s especially suited for sensitive or easily irritated skin, those new to retinol, and anyone who wants smoother, firmer, more radiant skin without redness or guesswork. Thoughtfully designed to suit most skin types, it’s one of the few gifts they’ll reach for night after night.

How long until I see results with the Retinol Cycling Duo?

You may notice a smoother, more radiant glow within 2 - 4 weeks. More visible improvements in fine lines, texture, and tone typically appear after 8 - 12 weeks of consistent use. Retinol works gradually but delivers long-term transformation.

What percentage of retinol is in the serum?

The Overnight Retinol Serum contains 0.5% liposome-encapsulated retinol. This next-gen delivery system ensures the retinol is released gradually and deeper into the skin—maximizing results while minimizing irritation.

Can I use the Cycling Duo with other active ingredients?

If you’re already using exfoliating acids or other strong actives, start slowly and monitor how your skin responds. We recommend introducing one new active at a time to avoid over-exfoliation.

Is it suitable for all skin types?

Yes, both products are formulated for all skin types - including sensitive, dry, and oily skin. However, we recommend performing a patch test prior to full application, especially if you’re prone to sensitivity.

Is the Cycling Duo safe for pregnancy or breastfeeding?

We recommend avoiding retinol during pregnancy or breastfeeding unless cleared by your doctor. You can use the Overnight Repair Serum on its own during this time. However, we always recommend consulting your doctor before introducing new skincare products during pregnancy or breastfeeding.

When should results be expected with the Retinol Cycling Duo + Moisture-Lock System?

Many people notice improved hydration, comfort, and radiance within the first 1–2 weeks of consistent nightly use. Smoother texture and more even-looking skin typically follow over 3–4 weeks, while firmer-looking skin and visible improvements in fine lines develop with continued use over 6–8 weeks. Because this system is designed to strengthen the skin barrier while it renews, results build gradually and comfortably — without the irritation that can delay progress.

We believe you deserve visible results: smoother, firmer, younger-looking skin that helps you feel confident every time you look in the mirror. That’s why every purchase is backed by our 60-day money-back guarantee. If you don’t love how your skin looks and feels, just send it back and get a full refund. No questions asked—even if the bottles are empty.