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The Full Anti-Aging System + Moisture Lock

Derma Botanica Overnight Retinol Serum bottle with text highlighting its benefits on a white background

Derma Botanica Overnight Retinol Serum before and after comparison of fine lines and wrinkles on skin with text indicating visible reduction.

Derma Botanica Overnight Retinol Serum is held by a hand, with product benefits displayed in a clinical study.

Derma Botanica Overnight Repair Serum bottle with text highlighting its benefits on a white background

Derma Botanica Overnight Repair Serum before and after comparison in the reduction of fine lines and wrinkles.

Derma Botanica Overnight Repair Serum is held by a hand, with product benefits displayed in a clinical study.

Adaptogenic Soothing Cream with labeled ingredients on a white background

Derma Botanica Adaptogenic Soothing Cream with text on benefits on a light background

Derma Botanica Moisture-Locking Face Oil with text highlighting its benefits on a white background

Derma Botanica Moisture-Locking Face Oil bottle on a reflective surface with a neutral background

The Full Anti-Aging System + Moisture Lock

Name: The Full Anti-Aging System + Moisture Lock
Brand: Derma Botanica
SKU: SET-FULML
Price: 156.00 USD
Availability: InStock

A complete retinol routine to wake up with younger-looking skin.

Our most advanced, dermatologist-developed nighttime system for skincare enthusiasts who want their best skin possible. This 4-step routine delivers clinical-level renewal, deep hydration, and targeted calming care for skin that looks smoother, firmer, and more radiant overnight.

Ideal for dry, mature, or sensitive skin—and with our highest bundled savings, it’s the best-value way to experience the full power of Derma Botanica.

$240.00

$156.00

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60-Day Money Back Guarantee

60-Day Money-Back Guarantee

See visible results after 60 days or your money back — even if the bottle’s empty.

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Dermatologist Developed

Expertly formulated with scientifically proven actives.

Dr. Dawn Queen MD, Board-Certified Dermatologist

"
As a dermatologist, I gravitate toward skincare that prioritizes clinically supported ingredients and thoughtful formulation, and that’s exactly what Derma Botanica delivers. When I use this routine, my skin stays balanced, hydrated, and comfortable.
"

What you'll notice

Week 1

Skin feels more hydrated and comfortable, with dryness and tightness reduced. Complexion begins to looks fresher, calmer, and more even.

Week 2-4

Fine lines appear softer, texture feels smoother, and skin looks firmer. Tone appears more even with a noticeably younger-looking appearance.

Ongoing Use

Skin continues to feel stronger, smoother, and more resilient. Contours appear firmer, dullness fades, and youthful radiance lasts throughout the day.

Emilia’s Journey | Duration 2 months

"two months in and the lines around my mouth are actually softer. my skin just looks like me again, idk how else to describe it."

Kellys’s Journey | Duration 4 weeks

"my skin is so sensitive everything makes me react. a month in with this and nothing. just hydrated in the morning, no stinging."

Ana’s Journey | Duration 6 weeks

"I was scared to try retinol because I've reacted before. 6 weeks in, nothing bad, and the lines around my mouth look softer."

Jessica's Journey | Duration 6 Weeks

"tried so many serums and nothing worked. 6 weeks with this one and the rough patches on my cheeks have calmed down. no irritation either."

Carmen’s Journey | Duration 2 weeks

"only 2 weeks and my skin feels way more hydrated. the uneven patches I've always had are smoother already, kinda shocked."

Megan’s Journey | Duration 3 months

"3 months in and my skin's brighter and more even. no flaking or redness either which always happens to me with retinols."

Good to know

How to use

Stage 1: Cycling — Build Tolerance

If you’re new to retinol or have sensitive skin, start gradually to allow your skin to adjust.

Retinol Nights: After cleansing, apply 2–3 pumps of Overnight Retinol Serum to your face and neck, avoiding the eye area. Follow with Adaptogenic Soothing Cream to calm and hydrate, then seal in benefits with the Moisture-Locking Face Oil.
Non-Retinol Nights: Replace retinol with Overnight Repair Serum to keep skin hydrated, balanced, and supported with visible anti-aging care. Follow with Adaptogenic Soothing Cream, then finish with the Moisture-Locking Face Oil for deep, lasting hydration.

Frequency: Begin with 2 nights per week, leaving at least one night between retinol applications. If tolerated without irritation, increase to every other night. Once comfortable, progress to nightly use.

Stage 2: Layering — Maximize Results

Once nightly retinol use feels comfortable, you can combine both overnight serums for enhanced benefits:

Apply Overnight Retinol Serum first to target fine lines, uneven texture, and tone.
Follow with Overnight Repair Serum to replenish hydration, strengthen the barrier, and maintain comfort.
Apply Adaptogenic Soothing Cream to calm, restore balance, and lock in active benefits.
Finish with Moisture-Locking Face Oil to seal in hydration and nourish skin for a supple, radiant look by morning.

Daily Care

Always apply SPF daily while using retinol.
Do not use if pregnant or breastfeeding.

Our 60 Day Guarantee

We believe you deserve visible results: smoother, firmer, younger-looking skin that helps you feel confident every time you look in the mirror.

That’s why every purchase is backed by our 60-day money-back guarantee.

If you don’t love how your skin looks and feels, just send it back and get a full refund. No questions asked—even if the bottles are empty.

Overnight Retinol

Water/Aqua/Eau, Caprylic/Capric Triglyceride, Propanediol, Sodium Cocoyl Amino Acids, Sarcosine Potassium Aspartate, Magnesium Aspartate, Butylene Glycol, Glycosphingolipids, Helianthus Annuus (Sunflower) Seed Oil, Centella Asiatica Leaf Extract, Phyllanthus Emblica Fruit Extract, Withania Somnifera Root Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Ectoin, Punica Granatum Extract, Leuconostoc/Radish Root Ferment Filtrate, Lauryl Glucoside, Myristyl Glucoside, Polyglyceryl-6 Laurate, Sodium Benzoate, Potassium Sorbate, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Glycerin, Phospholipids, Retinol, Phenoxyethanol, Polysorbate 20, Carbomer, Tocopherol Acetate, Citric Acid, Melatonin, Fragrance (Parfum).

Overnight Repair Serum

Water (Aqua), Propanediol, Glycerin, Niacinamide, Butylene Glycol, Oryza Sativa (Rice) Lipids, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Bakuchiol, Squalane, Glycosphingolipids, Panthenol, Tocopheryl Acetate, Sodium Benzoate, Hydrolyzed Soy Protein, Gluconolactone, Mandelic Acid, Potassium Sorbate, Centella Asiatica Leaf Extract, Phyllanthus Emblica Fruit Extract, Withania Somnifera Root Extract, Rice Amino Acids, Tetrasodium Glutamate Diacetate, Hydrolyzed Glycosaminoglycans, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Lactobionic Acid, Polyglutamic Acid, Phenoxyethanol, Proline, Pseudoalteromonas Exopolysaccharides, Ethylhexylglycerin, Hyaluronic Acid, Tremella Fuciformis Polysaccharide, Hydrolyzed Adansonia Digitata Seed Extract, Aspartic Acid, Citric Acid, Limonene, Citral, Coumarin, Linalool, Sodium Hydroxide.

Adaptogenic Soothing Cream

Water/Aqua/Eau, Helianthus Annuus (Sunflower) Seed Oil, Cetearyl Alcohol, Polysorbate 60, Rosa Damascena (Rose) Flower Distillate, Glycerin, Helianthus Annuus (Sunflower) Seed Oil, Centella Asiatica Leaf Extract, Phyllanthus Emblica Fruit Extract, Withania Somnifera Root Extract, Cocos Nucifera (Coconut) Oil, Stearic Acid, Squalane, Phenoxyethanol, Simmondsia Chinensis (Jojoba) Seed Oil, Tocopherol Acetate, Dimethylaminoethanol, Methyl Sulfonyl Methane, Xanthan Gum, Aloe Barbadensis Leaf Juice, Propylene Glycol, Aspalathus Linearis (Rooibus) Leaf Extract, Sodium Hyaluronate, Fragrance (Parfum).

Moisture-Locking Face Oil

Helianthus Annuus (Sunflower) Seed Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Salvia
Hispanica (Chia) Seed Oil, Centella Asiatica Leaf Extract, Phyllanthus Emblica Fruit Extract, Withania Somnifera Root Extract, Sclerocarya Birrea (Marula) Oil, Squalane, Oryza Sativa (Rice) Lipids, Euterpe Oleracea Sterols, Linoleic Acid, Oleic Acid, Linolenic Acid, Hippophae Rhamnoides Oil, Tocopherol Acetate, Bisabolol, Fragrance (Parfum).

Routine FAQs

Can I use this system if I’m new to retinol?

This system is ideal for those new to retinol. By alternating between the Overnight Retinol Serum and the Repair Serum, you can gradually build tolerance while the Soothing Cream and Face Oil provide hydration and comfort to keep skin balanced. We recommend starting with the Retinol Serum twice a week on non-consecutive nights, then slowly increasing frequency as your skin adjusts.

Will using four products feel too heavy on my skin?

Each formula is dermatologist-developed to be lightweight and non-comedogenic, designed to layer seamlessly and complement one another for a complete routine that helps you achieve visible results. The four steps work in harmony to renew, repair, hydrate, and soothe while supporting the barrier without feeling heavy or greasy, so skin stays balanced and comfortable.

Is it suitable for sensitive or redness-prone skin?

Absolutely. Our formulas are suitable for all skin types. Each step is dermatologist-developed and powered by our proprietary CalmResilience™ Complex to soothe visible redness and sensitivity, helping skin look calmer, stronger, and more resilient

Can I use this if I’m on prescription retinoids?

We recommend avoiding additional retinol if you are on prescription retinoids. However, you can still benefit from the Repair Serum, Soothing Cream, and Face Oil for repair, hydration and barrier support on non-prescription nights.

Is this routine safe for pregnancy or breastfeeding?

This routine contains retinol, which should be avoided during pregnancy and breastfeeding unless cleared by your doctor.

The Overnight Repair Serum, Adaptogenic Soothing Cream, and Moisture-Locking Face Oil contain no retinoids or harsh actives and are generally considered safe during pregnancy or breastfeeding. However, we recommend consulting your doctor before introducing any new skincare products during this time.

We believe you deserve visible results: smoother, firmer, younger-looking skin that helps you feel confident every time you look in the mirror. That’s why every purchase is backed by our 60-day money-back guarantee. If you don’t love how your skin looks and feels, just send it back and get a full refund. No questions asked—even if the bottles are empty.