Quiz Image

Get a personalized routine by Dr. Elena Morales.

TAKE QUIZ
1/7
The Full Anti-Aging System + Moisture Lock
The Full Anti-Aging System + Moisture Lock
The Full Anti-Aging System + Moisture Lock
The Full Anti-Aging System + Moisture Lock
The Full Anti-Aging System + Moisture Lock
The Full Anti-Aging System + Moisture Lock
The Full Anti-Aging System + Moisture Lock

The Full Anti-Aging System + Moisture Lock

A complete retinol routine to wake up with younger-looking skin.
4.85 (602 reviews)

Our most advanced, dermatologist-developed nighttime system for skincare enthusiasts who want their best skin possible. This 4-step routine delivers clinical-level renewal, deep hydration, and targeted calming care for skin that looks smoother, firmer, and more radiant overnight.

Ideal for dry, mature, or sensitive skin—and with our highest bundled savings, it’s the best-value way to experience the full power of Derma Botanica.

Free Cleanser worth $47
With every $100+ purchase
Regular price$240.00 Sale price$156.00
Regular price Save 35%
60-Day Money-Back Guarantee

60-Day Money-Back Guarantee

See visible results after 60 days or your money back — even if the bottle’s empty.

Free US Shipping Over $50

Free US Shipping Over $50

No hidden fees. Free delivery across the US mainland.

Dermatologist Developed

Dermatologist Developed

Expertly formulated with scientifically proven actives.

4 Steps. 1 Night Routine. Formulated to Work Together.

Each step in this system is designed to complement the next so you get smoother, stronger, brighter skin without irritation, dryness, or overload.

Step 1: Renew with Time-Release Retinol

Overnight Retinol Serum

Overnight Retinol Serum

Step 1: Renew with Time-Release Retinol

Overnight Retinol Serum

Formulated to deliver visible anti-aging results while minimizing irritation, this serum uses Liposome Encapsulation Technology™ for targeted, time-controlled release of retinol. The 3% Retinol Complex works in three phases: an immediate release to refine texture, an 8-hour gradual release to renew skin overnight, and deep-layer delivery where skin needs it most — all while being supported by Ectoin and Vitamin E to protect against environmental stressors and preserve hydration for lasting comfort.

The result: Skin that looks visibly smoother, firmer, and more even by morning, without redness or irritation.

  • Smooths visible fine lines, refines texture, and improves tone
  • Provides steady 8-hour renewal for visible results by morning
  • Reinforces the skin barrier to reduce irritation risk
  • Leaves skin feeling firmer, balanced, and refreshed
What's Inside +

  • Liposome Encapsulation Technology™

    Encapsulated in liposomes for controlled absorption, our retinol releases gradually over 8 hours to avoid harsh concentration spikes in the skin’s surface layers. This slow-release system smooths texture, improves firmness, and reveals younger-looking skin.

  • Ectoin + Vitamin E

    Locks in hydration and strengthens the skin barrier. Ectoin helps prevent dehydration, while Vitamin E calms visible irritation and defends against environmental stressors.

  • Melatonin + Amino Acid Complex

    Supports overnight recovery by syncing with the skin’s natural repair cycle, helping reduce visible inflammation, support collagen, and promote visible renewal.

  • CalmResilience™ Complex

    Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha helps fortify the skin barrier, reduce visible redness, and and smooth the look of stressed skin.

Dr. Sandy Skotnicki
Dr. Sandy Skotnicki MD, FRCPC, FABD, Board-Certified Dermatologist
"This smarter 8-hour time-release retinol from Derma Botanica offers maximum results with minimal irritation, making it perfect for those with sensitive skin."

What you'll notice

Week 1

Skin feels more hydrated and comfortable, with dryness and tightness reduced. Complexion begins to looks fresher, calmer, and more even.

Week 2-4

Fine lines appear softer, texture feels smoother, and skin looks firmer. Tone appears more even with a noticeably younger-looking appearance.

Ongoing Use

Skin continues to feel stronger, smoother, and more resilient. Contours appear firmer, dullness fades, and youthful radiance lasts throughout the day.

Emilia’s Journey | Duration 2 months

"I’ve noticed my skin looks smoother and more even since I started using this retinol serum consistently. The dullness and fine lines I was worried about are fading, and my complexion feels brighter and softer without the redness or flaking I was concerned about."

Kellys’s Journey | Duration 4 weeks

“I’ve been using this serum as part of my routine, and it’s made such a difference. My skin feels more hydrated and has a healthy brightness in the morning. I usually have a hard time with products that contain actives because my skin is so sensitive, but this one hasn’t caused any irritation at all.”

Ana’s Journey | Duration 6 weeks

“My skin looks firmer and way less tired since I started using the retinol. I was nervous at first since I’ve had reactions before. But I used it every 2 nights on & off like they said and it’s been fine. I wish I started using it earlier!”

Jessica's Journey | Duration 6 Weeks

"Six weeks in and my skin looks so much smoother. The rough texture around my cheeks has softened, and overall my skin feels calmer and more balanced. I’ve tried a lot of serums before, but this is the first one that gave me visible results without irritation."

Carmen’s Journey | Duration 2 weeks

“This left my skin feeling deeply moisturized and helped smooth out the uneven areas I’ve always struggled with. I wasn’t expecting a big transformation, so the results really surprised me. It’s definitely become one of those products I’d 100% recommend to anyone.”

Megan’s Journey | Duration 3 months

“The retinol serum has made my skin look smoother and more even. I’ve always struggled with uneven tone and dullness, but I was worried retinol would be too harsh. This one felt surprisingly gentle. I didn’t get the flaking or redness I had with other retinol products.”

Good to know

Clean formula | Safe for all skin types | No parabens, sulfates, phthalates, or synthetic dyes | Non-comedogenic | Vegan | Cruelty-free

Overnight Retinol

Water/Aqua/Eau, Caprylic/Capric Triglyceride, Propanediol, Sodium Cocoyl Amino Acids, Sarcosine Potassium Aspartate, Magnesium Aspartate, Butylene Glycol, Glycosphingolipids, Helianthus Annuus (Sunflower) Seed Oil, Centella Asiatica Leaf Extract, Phyllanthus Emblica Fruit Extract, Withania Somnifera Root Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Ectoin, Punica Granatum Extract, Leuconostoc/Radish Root Ferment Filtrate, Lauryl Glucoside, Myristyl Glucoside, Polyglyceryl-6 Laurate, Sodium Benzoate, Potassium Sorbate, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Glycerin, Phospholipids, Retinol, Phenoxyethanol, Polysorbate 20, Carbomer, Tocopherol Acetate, Citric Acid, Melatonin, Fragrance (Parfum).


Overnight Repair Serum

Water/Aqua/Eau, Glycerin, Centella Asiatica Leaf Extract, Phyllanthus Emblica Fruit Extract, Withania Somnifera Root Extract, Propanediol, Niacinamide, Butylene Glycol, Glycosphingolipids, Phenoxyethanol, Oryza Sativa (Rice) Lipids, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Hyaluronate, Hydrolyzed Glycosaminoglycans, Hydrolyzed Hyaluronic Acid, Hyaluronic Acid, Tremella Fuciformis Polysaccharide, Polyglutamic Acid, Mandelic Acid, Aspartic Acid, Gluconolactone, Lactobionic Acid, Pseudoalteromonas Exopolysaccharides, Hydrolyzed Soy Protein, Rice Amino Acids, Hydrolyzed Adansonia Digitata Seed Extract, Proline, Tocopherol Acetate, Squalane, Bakuchiol, Oenothera Biennes Oil, Panthenol, Sodium Benzoate, Potassium Sorbate, Fragrance (Parfum).


Adaptogenic Soothing Cream

Water/Aqua/Eau, Helianthus Annuus (Sunflower) Seed Oil, Cetearyl Alcohol, Polysorbate 60, Rosa Damascena (Rose) Flower Distillate, Glycerin, Helianthus Annuus (Sunflower) Seed Oil, Centella Asiatica Leaf Extract, Phyllanthus Emblica Fruit Extract, Withania Somnifera Root Extract, Cocos Nucifera (Coconut) Oil, Stearic Acid, Squalane, Phenoxyethanol, Simmondsia Chinensis (Jojoba) Seed Oil, Tocopherol Acetate, Dimethylaminoethanol, Methyl Sulfonyl Methane, Xanthan Gum, Aloe Barbadensis Leaf Juice, Propylene Glycol, Aspalathus Linearis (Rooibus) Leaf Extract, Sodium Hyaluronate, Fragrance (Parfum).


Moisture-Locking Face Oil

Helianthus Annuus (Sunflower) Seed Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Salvia
Hispanica (Chia) Seed Oil, Centella Asiatica Leaf Extract, Phyllanthus Emblica Fruit Extract, Withania Somnifera Root Extract, Sclerocarya Birrea (Marula) Oil, Squalane, Oryza Sativa (Rice) Lipids, Euterpe Oleracea Sterols, Linoleic Acid, Oleic Acid, Linolenic Acid, Hippophae Rhamnoides Oil, Tocopherol Acetate, Bisabolol, Fragrance (Parfum).

4 Steps. 1 Night Routine. Formulated to Work Together.

Each step in this system is designed to complement the next so you get smoother, stronger, brighter skin without irritation, dryness, or overload.

Step 1: Renew with Time-Release Retinol

Overnight Retinol Serum

Overnight Retinol Serum

Step 1: Renew with Time-Release Retinol

Overnight Retinol Serum

Formulated to deliver visible anti-aging results while minimizing irritation, this serum uses Liposome Encapsulation Technology™ for targeted, time-controlled release of retinol. The 3% Retinol Complex works in three phases: an immediate release to refine texture, an 8-hour gradual release to renew skin overnight, and deep-layer delivery where skin needs it most — all while being supported by Ectoin and Vitamin E to protect against environmental stressors and preserve hydration for lasting comfort.

The result: Skin that looks visibly smoother, firmer, and more even by morning, without redness or irritation.

  • Smooths visible fine lines, refines texture, and improves tone
  • Provides steady 8-hour renewal for visible results by morning
  • Reinforces the skin barrier to reduce irritation risk
  • Leaves skin feeling firmer, balanced, and refreshed
What's Inside

  • Liposome Encapsulation Technology™

    Encapsulated in liposomes for controlled absorption, our retinol releases gradually over 8 hours to avoid harsh concentration spikes in the skin’s surface layers. This slow-release system smooths texture, improves firmness, and reveals younger-looking skin.

  • Ectoin + Vitamin E

    Locks in hydration and strengthens the skin barrier. Ectoin helps prevent dehydration, while Vitamin E calms visible irritation and defends against environmental stressors.

  • Melatonin + Amino Acid Complex

    Supports overnight recovery by syncing with the skin’s natural repair cycle, helping reduce visible inflammation, support collagen, and promote visible renewal.

  • CalmResilience™ Complex

    Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha helps fortify the skin barrier, reduce visible redness, and and smooth the look of stressed skin.

Routine FAQs

Customer Reviews

Based on 602 reviews
90%
(544)
5%
(31)
4%
(23)
0%
(3)
0%
(1)
A
Annette W.
New favorite

I’m honestly shocked. I’ve tried tons of serums and always flake or get red. Not with this one. It goes on smooth, no sting, and my skin feels soft in the morning. I even stopped wearing foundation some days!

K
Kelly P.
Can’t live without!

I feel like I’ve had less breakouts since I started.

A
April B.
New holy grail

I’m on my 2nd bottle and it still feels amazing every time

C
Christy H.
Surprisingly soothing

Hydrating and effective. Use it 3 nights a week and my skin is thriving.

C
Christina
LOVE THIS STUFF!!!

No irritation, no dryness, just glowy happy skin. What else do u need in a serum??

Load More

We believe you deserve visible results: smoother, firmer, younger-looking skin that helps you feel confident every time you look in the mirror. That’s why every purchase is backed by our 60-day money-back guarantee. If you don’t love how your skin looks and feels, just send it back and get a full refund. No questions asked—even if the bottles are empty.

Remove this item?

Are you sure you want to remove