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Derma Botanica Overnight Retinol Serum bottle with text highlighting its benefits on a white background

Derma Botanica Retinol Serum Ingredients with text labels on a serum drop.

Derma Botanica Overnight Retinol Serum dosage and usage instructions on a gray background.

Derma Botanica Overnight Retinol Serum before and after comparison of fine lines and wrinkles on skin with text indicating visible reduction.

Derma Botanica Overnight Retinol Serum before and after comparison of skin texture, with a visible improvement after using the product.

Woman holding a Derma Botanica Overnight Retinol Serum close to her face.

Overnight Retinol Serum

Smoother, firmer, more even skin without redness, peeling, or irritation.

30ml / 1 oz. fl

Developed with dermatologists, this 0.5% Liposomal Retinol Serum with calming adaptogens visibly smooths fine lines, improves uneven tone, and reinforces the skin barrier.

The 8-Hour Time Release System delivers retinol while you sleep for visible anti-aging results without redness, peeling, or flaking. Gentle enough for sensitive skin, it restores a smoother, firmer, and younger-looking complexion overnight.

Select Your Supply

1 Bottle

$74.00

Start gently, see the glow for yourself

60-Day Money-Back Guarantee

See visible results after 60 days or your money back — even if the bottle’s empty.

Free US Shipping Over $50

No hidden fees. Free delivery across the US mainland.

Dermatologist Developed

Expertly formulated with scientifically proven actives.

What you'll notice

Week 1

Your skin starts to feel smoother, calmer, and more balanced, without dryness or stinging.

Week 2-4

Fine lines look softened, texture feels smoother, and skin tone appears more even, for a brighter, youthful-looking complexion.

Ongoing Use

Skin looks clearer and more radiant. Fine lines and wrinkles appear softened, dark spots look diminished, and pores appear refined, leaving many users confident about going makeup-free.

Emilia’s Journey | Duration 2 months

"I’ve noticed my skin looks smoother and more even since I started using this retinol serum consistently. The dullness and fine lines I was worried about are fading, and my complexion feels brighter and softer without the redness or flaking I was concerned about."

Olivia’s Journey | Duration 3 weeks

"My skin looks brighter and more full of life. My tone is more even, and there’s a healthy glow coming through. I started using retinol to stay on top of early signs of aging, and this one has made a real difference!"

Clara’s Journey | Duration 2 months

"The dark spots on my cheeks have lightened a lot over the past two months, and my skin feels firmer with the lines on my face looking softer. It’s the first time in a long while I’ve felt confident without covering them up with makeup."

Ana’s Journey | Duration 6 weeks

“My skin looks firmer and way less tired since I started using the retinol. I was nervous at first since I’ve had reactions before. But I used it every 2 nights on & off like they said and it’s been fine. I wish I started using it earlier!”

Megan’s Journey | Duration 3 months

“The retinol serum has made my skin look smoother and more even. I’ve always struggled with uneven tone and dullness, but I was worried retinol would be too harsh. This one felt surprisingly gentle. I didn’t get the flaking or redness I had with other retinol products.”

Sophie’s Journey | Duration 4 Weeks

"I’ve always been bothered by fine lines and dark spot patches on my face. Since I started using this serum, the spots look lighter and the lines aren’t as noticeable. My skin feels fresher overall and has a healthy glow."

Why It Works

Liposomal Retinol Complex

Encapsulated in liposomes that mimic skin’s natural lipids, retinol penetrates deeper within the skin’s surface for greater effectiveness and reduced irritation.

8-Hour Time Release 

Retinol is gradually released while you sleep, renewing the skin with visible anti-aging results without overloading it with actives.

Built-In Barrier Support

Soothing and hydrating actives are integrated into the formula to reinforce the skin barrier, keeping it calm and resilient while liposomal retinol delivers results.

One Step, Multiple Benefits

Firms, brightens, smooths, and evens tone in a single serum, streamlining your routine without compromising results.

Dr. Dawn Queen MD, Board-Certified Dermatologist

"
A stand out retinol formula with gradual-release liposomal technology and barrier-supporting ingredients to target lines, texture, and discoloration while staying gentle on the skin. Over time, I noticed my skin looked more even and refreshed, without the irritation that can sometimes come with retinol.
"

Good to know

How to use

Step 1: Apply at Night

Use 2–3 pumps on clean, dry skin. Avoid the eye area.

Step 2: Moisturize (optional)

Follow with your preferred moisturizer to lock in hydration. If using our Adaptogenic Soothing Cream, apply it after the serum.

Usage Frequency Guidelines:

Stage 1: Cycling — Build Tolerance

If you are new to retinol or have sensitive skin, start gradually to help your skin adjust.

Apply 2–3 pumps to clean, dry skin twice a week, leaving at least one day between applications.
If your skin tolerates this without irritation, increase usage to every other night.
Once your skin adjusts to this frequency without irritation, progress to nightly use.

On Non-Retinol Nights 

Use the Overnight Repair Serum on alternate nights to complement retinol in your routine. Powered by the Multi-Layer Hydration System™ and Triple Renewal Complex™, it strengthens the barrier, calms sensitivity, and delivers retinol-like firming, brightening, and smoothing to help maintain visible anti-aging results.

Stage 2: Layering — Maximize Results

Once nightly retinol use feels comfortable, you can combine both overnight serums for enhanced benefits:

Apply the Overnight Retinol Serum first to target fine lines, uneven texture, and tone.
Follow with the Overnight Repair Serum to replenish hydration, reinforce the barrier, and minimize sensitivity. Together, they allow retinol to work effectively while keeping skin resilient — for smoother, firmer, and more even-looking results over time.

Additional Notes

Always apply SPF daily while using retinol.
Do not use if pregnant or breastfeeding.

Our 60 Day Guarantee

We believe you deserve visible results: smoother, firmer, younger-looking skin that helps you feel confident every time you look in the mirror.

That’s why every purchase is backed by our 60-day money-back guarantee.

If you don’t love how your skin looks and feels, just send it back and get a full refund. No questions asked—even if the bottles are empty.

Kelly R.

Verified Purchase

Obsessed!!

I was nervous to try this serum because it was my first time using retinol and I have sensitive skin. I did not experience any redness or irritation and truly believe it's due to its slow release properties. It was so gentle, yet effective, and actually felt good on my skin. I highly recommend this encapsulated retinol to anyone with sensitive skin!

Katelynn A.

Verified Purchase

This stuff is amazing!!! 🤩

As a skincare junkie, I’ve tried sooo many retinols and even after 1 use they’ve always made me red and peel, but I used this retinol EVERY SINGLE NIGHT for 4 weeks straight and it didn’t make me red or peel a single time plus it’s given me the brightest, glowing skin making it gentle, yet very effective!!! Absolutely love this stuff!!!

Amanda H.

Verified Purchase

It's changed my skin to glowing!!

A lovley light creamy serum .. I only use a little the photo shows just one pump! And it glides across the face and jawline. Absorbing super quick!

I've been using over the 2 weeks and love how my skin feels. I wake up feeling hydrated and plump and the condition overall has improved immensely.. really high quality active ingredients that don't irritate the skin. Just brilliant.

Read all reviews

What’s inside

Liposome Encapsulation Technology™
Encapsulated in liposomes for controlled absorption, our retinol releases gradually over 8 hours to avoid harsh concentration spikes in the skin’s surface layers. This slow-release system smooths texture, improves firmness, and reveals younger-looking skin.
Ectoin + Vitamin E
Locks in hydration and strengthens the skin barrier. Ectoin helps prevent dehydration, while Vitamin E calms visible irritation and defends against environmental stressors.
Melatonin + Amino Acid Complex
Supports overnight recovery by syncing with the skin’s natural repair cycle, helping reduce visible inflammation, support collagen, and promote visible renewal.
CalmResilience™ Complex
Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha helps fortify the skin barrier, reduce visible redness, and and smooth the look of stressed skin.

FULL INGREDIENTS LIST

Product FAQs

How long until I see results?

You may notice a smoother, more radiant glow within 2 - 4 weeks. More visible improvements in fine lines, texture, and tone typically appear after 8 - 12 weeks of consistent use. Retinol works gradually but delivers long-term transformation.

What percentage of retinol is in the serum?

The Overnight Retinol Serum contains 0.5% liposome-encapsulated retinol. This next-gen delivery system ensures the retinol is released gradually and deeper into the skin—maximizing results while minimizing irritation.

What makes this retinol different from others?

Unlike traditional formulas, this serum uses liposomal encapsulation technology to deliver retinol more efficiently with less surface irritation. It also includes our proprietary CalmResilience™ Complex, designed to soothe, hydrate, and support the skin barrier—making it ideal even for sensitive or first-time users.

Is this serum suitable for all skin types?

Yes, it's formulated for all skin types - including sensitive, dry, and oily skin. However, we recommend performing a patch test prior to full application, especially if you’re prone to sensitivity.

Is it safe to use during pregnancy or breastfeeding?

We recommend avoiding retinol during pregnancy or breastfeeding unless cleared by your doctor.

What should I do if I experience irritation?

Mild redness or dryness is normal when starting retinol. If you experience irritation:

Reduce usage to once or twice weekly
Always follow with a moisturizer
Apply sunscreen daily, as retinol increases sun sensitivity

If irritation persists, discontinue use and consult a dermatologist.

We believe you deserve visible results: smoother, firmer, younger-looking skin that helps you feel confident every time you look in the mirror. That’s why every purchase is backed by our 60-day money-back guarantee. If you don’t love how your skin looks and feels, just send it back and get a full refund. No questions asked—even if the bottles are empty.