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Overnight Repair Serum

Plumps, smooths, and strengthens for a youthful complexion.

Wake up to visibly firmer, smoother, younger-looking skin. This dermatologist-developed overnight serum targets visible signs of aging with 5D Hyaluronic Acid for deep hydration, Niacinamide to refine tone and strengthen the barrier, and Adaptogenic Botanicals to calm stressed skin.

The result: a refreshed, resilient, and renewed complexion by morning.

SELECT QUANTITY:

1 Bottle

$68.00

Start gently, see the glow for yourself

2 Bottle

$116.00 /each

Full 60-day smoothing cycle

Save $20

3 Bottle

$143.00 /each

Best deal for long-term results

Save $61

60-Day Money-Back Guarantee

See visible results after 60 days or your money back — even if the bottle’s empty.

Free US Shipping Over $50

No hidden fees. Free delivery across the US mainland.

Dermatologist Developed

Expertly formulated with scientifically proven actives.

What you'll notice

Week 1

Skin begins to feel deeply hydrated, soothed, and comfortable, with a visibly calmer appearance and reduced dryness.

Week 2-4

Texture looks smoother and more refined. Fine lines appear softened, redness looks reduced, and skin feels stronger and more youthful.

Ongoing Use

Skin remains hydrated and radiant, with visibly softer lines, a more even tone, and a calm, balanced look you’ll love.

Kellys’s Journey | Duration 4 weeks

“This serum has been such a nice add to my routine. My skin feels more hydrated and looks brighter in the morning. I have really sensitive skin and usually can’t use anything with actives, but this didn’t irritate me at all. Didn’t expect it to work this well.”

Nicole’s Journey | Duration 8 weeks

"Love this serum. My skin looks healthier overall — brighter, even, and way more hydrated in the morning. I’ve got sensitive skin so I’ve always avoided strong actives, but this felt really soothing. Didn’t expect it to become my go-to but here we are."

Carmen’s Journey | Duration 2 weeks

“This made my skin feel very moisturized and smoothed out some of the uneven patches I always had trouble with. I wasn’t looking for a dramatic change, just something that made me look more rested. And this actually delivered. Would 100% recommend.”

Jessica's Journey | Duration 6 Weeks

Six weeks in and my skin looks so much smoother. The rough texture around my cheeks has softened, and overall my skin feels calmer and more balanced. I’ve tried a lot of serums before, but this is the first one that gave me visible results without irritation

Why It Works

Targeted Hydration in Every Layer

Our Multi-Layer Hydration System™ delivers deep, lasting moisture to plump and smooth within the skin’s surface layers.

Repair Without Irritation 

Triple Renewal Complex™ reduces visible signs of aging, improves firmness, and refines texture while keeping skin calm and comfortable.

Strengthened Barrier Support 

Soothing botanicals fortify the skin barrier, calm visible stress, and support its natural renewal.

One formula replaces 3 serums.

Hydrates, smooths, firms, and boosts resilience in a single step, simplifying your routine without compromising results.

Science-Backed Formulation

Developed with board-certified dermatologists using clinically proven actives for visible anti-aging results.

Dr. Sandy Skotnicki MD, FRCPC, FABD, Board-Certified Dermatologist

"
In my experience, patients get the best results when their routines are simple and easy to stick to. Derma Botanica’s multi-functional formulas reduce the number of products needed, making consistency easy, without compromising on efficacy.
"

How to use

Step 1: Prep Your Skin 

Begin with a clean, dry face to ensure optimal absorption of the serum’s active ingredients.

Step 2: Apply Serum

Dispense 2–3 drops of the serum onto your fingertips and gently pat onto your face and neck, avoiding the eye area. Patting rather than rubbing helps the formula absorb evenly.

Step 3: Let It Absorb

Allow 1–2 minutes for the serum to fully absorb into your skin before applying additional products.

Step 4: Seal in Hydration

Follow with Adaptogenic Soothing Cream or Moisture-Locking Face Oil to lock in moisture and support the serum’s repairing benefits overnight.

Our 60 Day Guarantee

We believe you deserve visible results: smoother, firmer, younger-looking skin that helps you feel confident every time you look in the mirror.

That’s why every purchase is backed by our 60-day money-back guarantee.

If you don’t love how your skin looks and feels, just send it back and get a full refund. No questions asked—even if the bottles are empty.

Erykah T.

Verified Purchase

If you have dry skin you need this!

The hydration my skin received after using this for a couple weeks was insane. I love how it smells. I love how it feels. My skin is way more hydrated. I love it so much.

Katelynn A.

This serum is a MUST HAVE!!! 🤩

This overnight skin serum truly feels like my skin is getting a big ol drink of water every night when I apply it and every morning when I wake up, my skin is nice and glowy like I just got home from the medspa. It’s lightweight so it doesn’t have that heavy, greasy feeling yet so effective at the same time. YAY for the power of plants!!! This is definitely a must have in my skincare game from now on!!

Kelly R.

Verified Purchase

My All-Time Favorite Serum!

This Overnight Repair Serum is an absolute must have! So much goodness in one bottle...Hyaluronic Acid, Bakuchiol AND Niacinamide! My skin has never looked so hydrated and so smooth. I love the way it feels when applied and it has such a wonderful smell! Highly recommend!

Read all reviews

What’s inside

Triple Renewal Complex™
Bakuchiol, Niacinamide, and Plant Collagen visibly smooth fine lines, enhance firmness, and refine texture to deliver anti-aging benefits without irritation.
Multi-Layer Hydration System™
Five molecular weights of Hyaluronic Acid with Ceramides and Squalane deliver deep, lasting hydration, lock in moisture, and visibly plump the skin for a smoother look.
CalmResilience™ Complex
Our proprietary adaptogen blend of Centella, Amla, and Ashwagandha calms visible redness, reduces signs of stress, and supports the skin’s natural resilience for a balanced, healthy-looking complexion.

FULL INGREDIENTS LIST

Shared by people who tried it

Product FAQs

How long until I see results with the Overnight Repair Serum?

Most users notice a softer, more hydrated glow after the first few uses. With continued nightly use, skin typically appears smoother, calmer, and more even-toned within 2–4 weeks. The Overnight Repair Serum is designed to restore and strengthen your skin barrier over time, so consistency is key.

What does the Overnight Repair Serum do? 

This serum is a barrier-strengthening, recovery-focused treatment designed to hydrate, calm, and support skin overnight. It helps repair dryness, reduce redness, and rebalance stressed or over-exfoliated skin. It’s also the perfect complement to active ingredients like retinol or acids.

Is the Overnight Repair Serum suitable for all skin types?

Yes, the Overnight Repair Serum is safe for all skin types, including sensitive, acne-prone, and dry skin. Its minimal, non-comedogenic formula supports hydration and barrier health without clogging pores or causing breakouts.

What makes this different from a typical hydrating serum?

While most hydrating serums focus on water content, this formula does more. It combines barrier-repair lipids, soothing adaptogens, and restorative peptides to actively rebuild and strengthen the skin’s protective layer—not just hydrate it.

Can I use the Overnight Repair Serum every night?

Absolutely. It’s gentle enough for nightly use, even twice daily if needed. Use it on its own or rotate it with our Overnight Retinol Serum depending on your skin’s needs.

Is the Overnight Repair Serum safe for pregnancy or breastfeeding?

Yes—this formula contains no retinoids or harsh actives, making it generally safe for pregnancy and breastfeeding. However, we always recommend consulting your doctor before introducing new skincare products during pregnancy or breastfeeding.

Age range: 45-54

Skin type: Dry

Powerful Plants in a bottle

This is by far the best I've tried. and at my age I've tried a lot! Its rare to find plant based collagen and the plant retinol, bakuchiol, combined with adaptogenic botanicals and high cotent of skin plumping, Hyaluronic Acid. The ingredients are expertly mixed to exacting standards, so I know its safe; that's worth every penny. My skin feels soft, more even toned, less redness, and looks fresher everyday. im so pleased I found it.

Age range: 35-44

Skin type: Dry

My All-Time Favorite Serum!

Age range: 25-34

Skin type: Combination

If you have dry skin you need this!

The hydration my skin received after using this for a couple weeks was insane. I love how it smells. I love how it feels. My skin is way more hydrated. I love it so much.

Age range: 35-44

Skin type: Combination

This serum is a MUST HAVE!!! 🤩

Age range: 35-44

Skin type: Sensitive

Aesthetician approved!

I love this overnight repair serum because it is so gentle yet really effective. Whenever my skin is feeling overly sensitized, I use this. I know I’m going to get great results and my skin’s gonna glow in the morning, but it won’t be irritated. My clients love it and I use it for my sensitive skin clients. Zero irritation zero sensitivity.

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We believe you deserve visible results: smoother, firmer, younger-looking skin that helps you feel confident every time you look in the mirror. That’s why every purchase is backed by our 60-day money-back guarantee. If you don’t love how your skin looks and feels, just send it back and get a full refund. No questions asked—even if the bottles are empty.

Get a personalized routine by Dr. Elena Morales.